Edward T Morgan Selected Research

Cytochrome P-450 Enzyme System (Cytochrome P450)

1/2022	High-Throughput Production of Diverse Xenobiotic Metabolites with Cytochrome P450-Transduced Huh7 Hepatoma Cell Lines.
1/2020	Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6.
2/2014	Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
1/2014	Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
10/2012	Selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in severe combined immune-deficient mice.
8/2011	Selective role for tumor necrosis factor-α, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
11/2010	Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
3/2009	Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models.
2/2009	TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
2/2009	Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium.

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Edward T Morgan Research Topics

Disease

20	Infections 07/2019 - 12/2002
18	Inflammation (Inflammations) 01/2020 - 12/2002
5	Colitis 04/2014 - 02/2008
4	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2014
2	Malaria 07/2019 - 09/2015
2	Neoplasms (Cancer) 09/2015 - 02/2008
2	Bacterial Infections (Bacterial Infection) 02/2009 - 02/2008
1	Parasitic Diseases (Parasitic Disease) 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 09/2015
1	Fibrosis (Cirrhosis) 09/2015
1	Hypertension (High Blood Pressure) 06/2014
1	Acute-Phase Reaction 06/2014
1	Cholestasis 04/2014
1	Schistosomiasis mansoni 01/2014
1	Schistosomiasis (Bilharziasis) 01/2014
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2009
1	Ulcerative Colitis 02/2008
1	Sepsis (Septicemia) 01/2005

Drug/Important Bio-Agent (IBA)

18	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2022 - 12/2002
12	EnzymesIBA 01/2022 - 12/2002
9	Pharmaceutical PreparationsIBA 07/2019 - 01/2006
8	Messenger RNA (mRNA)IBA 09/2015 - 12/2002
8	CytokinesIBA 06/2014 - 03/2006
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 12/2002
6	LipopolysaccharidesIBA 06/2014 - 03/2006
5	CytochromesIBA 01/2022 - 09/2007
4	Toll-Like Receptor 4IBA 02/2009 - 03/2006
3	4,6-dinitro-o-cresol (DNOC)IBA 10/2012 - 03/2009
3	Mixed Function Oxygenases (Monooxygenases)IBA 10/2012 - 03/2009
3	Dextran SulfateIBA 03/2009 - 02/2008
3	EndotoxinsIBA 02/2009 - 08/2005
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 01/2020
2	UbiquitinIBA 01/2020 - 01/2020
2	Clodronic Acid (Clodronate)IBA 09/2015 - 08/2011
2	Cytochrome P-450 CYP4A (Alkane 1 Monooxygenase)IBA 06/2014 - 08/2011
2	dimethylethylsilylimidazoleIBA 04/2014 - 01/2014
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2014 - 08/2005
2	Protein Isoforms (Isoforms)IBA 03/2009 - 03/2006
1	XenobioticsIBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020
1	Nicotine FDA Link 01/2020
1	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2020
1	SmokeIBA 01/2020
1	Antimalarials (Antimalarial Agents)IBA 07/2019
1	Quinine (Quinson)FDA Link 07/2019
1	Erythropoietin FDA Link 09/2015
1	Liposomes (Liposome)IBA 09/2015
1	Phosphotransferases (Kinase)IBA 09/2015
1	Carbon Tetrachloride (Tetrachloromethane)IBA 09/2015
1	Chemokine ReceptorsIBA 09/2015
1	RNA (Ribonucleic Acid)IBA 09/2015
1	tyrosine receptor (receptor, tyrosine)IBA 09/2015
1	ChemokinesIBA 09/2015
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2015
1	SaltsIBA 06/2014
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 06/2014
1	Bile Acids and Salts (Bile Acids)IBA 04/2014
1	XENP 1595IBA 02/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2014
1	Cytochrome P-450 CYP3AIBA 02/2014
1	LipidsIBA 01/2014
1	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)IBA 01/2014
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2014
1	Type I Tumor Necrosis Factor ReceptorsIBA 08/2011
1	Interleukin-6 (Interleukin 6)IBA 11/2010
1	Interferon-gamma (Interferon, gamma)IBA 11/2010
1	InterferonsIBA 11/2010
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 11/2010
1	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 03/2009
1	Lipopolysaccharide ReceptorsIBA 02/2009
1	Stearoyl-CoA DesaturaseIBA 02/2008
1	Cytochrome P-450 CYP2C8IBA 09/2007
1	Leukotriene B4IBA 05/2007
1	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 03/2006
1	Uridine Diphosphate (UDP)IBA 03/2006
1	PPAR alphaIBA 08/2005

Therapy/Procedure

1	Intraperitoneal Injections 07/2019
1	Sodium-Restricted Diet (Diet, Sodium Restricted) 06/2014
1	Cardiopulmonary Resuscitation (CPR) 01/2014
1	Drug Therapy (Chemotherapy) 02/2008